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Depof (Imipramine)

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Depof is a tricyclic antidepressant used to treat symptoms of depression. Depof is sometimes used to treat bed-wetting in children ages 6 and older. Depof may also be used for purposes not listed in this medication guide.

Other names for this medication:
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Also known as: Imipramine


Imipramine is used to treat depression. It belongs to a group of medicines known as tricyclic antidepressants (TCA). These medicines are thought to work by increasing the activity of a chemical called serotonin in the brain.

Imipramine tablets are also used to treat enuresis (bedwetting) in children.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain imipramine. It may not be specific to Depof-PM. Please read with care.

Take this medicine only as directed by your doctor to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (capsules): For depression: Adults—At first, 75 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 200 mg per day, unless you are in the hospital. Some hospitalized patients may need higher doses. Teenagers and older adults—At first, 25 to 50 mg per day using the tablets. Your doctor may adjust your dose as needed and switch you to the capsule form. However, the dose is usually not more than 100 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): For depression: Adults—At first, 75 milligrams (mg) per day. Your doctor may adjust your dose as needed. However the dose is usually not more than 200 mg per day. Some hospitalized patients may need higher doses. Teenagers and older adults—30 to 40 mg per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 100 mg per day. Children—Use and dose must be determined by your doctor. For enuresis (bedwetting): Children 6 years of age and older—At first, 25 milligrams (mg) once a day, taken 1 hour before bedtime. Your doctor may adjust the dose as needed. Children younger than 6 years of age—Use and dose must be determined by your doctor.


If you overdose Generic Depof and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Depof overdosage: agitation, bluish skin, convulsions, difficulty breathing, dilated pupils, drowsiness, heart failure, high fever, involuntary writhing or jerky movements, irregular or rapid heartbeat, lack of coordination, low blood pressure, overactive reflexes, restlessness, rigid muscles, shock, stupor, sweating, vomiting.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Depof are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Depof if you are allergic to it, or if:

you recently had a heart attack; or you are allergic to other antidepressants (amitriptyline, amoxapine, clomipramine, desipramine, doxepin, nortriptyline, protriptyline, or trDepof).

Do not use Depof if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.

Tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone.

Tell your doctor if you have ever had:

heart disease, stroke, or seizures; bipolar disorder (manic-depression), schizophrenia or other mental illness; kidney or liver disease; overactive thyroid; narrow-angle glaucoma; or problems with urination.

Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

It is not known whether Depof will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breastfeed while using Depof.

Do not give this medicine to a child without medical advice. Depof is not approved to treat depression in anyone younger than 18 years old. This medicine should not be used to treat bed-wetting in a child younger than 6 years old.

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The present review provides an update of the currently available (proto-) types of device-assisted enteroscopy (DAE). The steady state kinetics of three abortive initiations at T7 promoter A3 were studied in detail. Teaching Video NeuroImages: Bent spine syndrome as an early presentation of late-onset Pompe disease. A novel approach for biomechanical spine analysis: Mechanical response of vertebral bone augmentation by kyphoplasty to stabilise thoracolumbar burst fractures. Commercially available lipid-based transfection reagents are widely used to deliver DNA to cells. Addition of Y-27632 to vinculin-null outgrowth cultures further stimulates migration an additional 2-fold, supporting the conclusion that Rho/ROCK and vinculin regulate parietal endoderm outgrowth by distinct pathways. Here we demonstrate that membrane-type 3 MMP, MT3-MMP, is expressed in mesenchymal tissues of the skeleton and in peri-skeletal soft connective tissue. In our clinic, 10 patients with severe cervical burn contractures were reconstructed with preexpanded supraclavicular artery flaps between 2005 and 2012. One study reported ankylosis of bilateral coronoid processes, in which coronoidectomies were necessary. There is a growing hope that systems-level consideration may provide a new perspective to overcome such current difficulties of drug discovery and development.

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Here, we evaluated whether a Bio-Gide collagen membrane (Geistlich Pharma AG, Wolhusen, Switzerland) has efficacy in promoting dentin formation in regenerative endodontics. New Concepts for Increasing the Efficiency in Directed Evolution of Stereoselective Enzymes. The major advantages of such a PCR-based approach are its ability to obtain unbiased FGFR mRNA expression patterns and to detect transcripts present in low copy number. Some Concrete Problems of Health Administration -A Symposium: Staff Education in Chicago. To explore the clinical features of neuromyelitis optica (NMO) patients, and to study the distribution of Chinese medical syndrome types and the pathogenesis of NMO. Lower respiratory tract infection caused by influenza virus A and influenza virus B in Wenzhou, China: a clinical analysis of 366 children. We employed a retrospective cohort approach using longitudinal data in which gender-specific subject groups were followed from the beginning of duty as a registered nurse to the occurrence of an outcome, or to censoring due to completion of service or the end of available data. The mechanism of diuresis in the nephrotic syndrome studied by a contingency technique. In this study, we investigated the anti-tumor effect of MLN4924 in human clear cell renal carcinoma (ccRCC).

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Gastrointestinal tolerance, fat absorption, plasma ketone and urinary dicarboxylic acid levels in low-birth-weight infants fed different amounts of medium-chain triglycerides in formula. The correct diagnosis of traction alopecia is important in order to avoid unnecessary treatments. Physico-chemical characteristics of corrosion scales in old iron pipes. Activities of the center for the treatment of developmental defects of the face during the period of Jan. Antibiotics may be safely recommended in patients with high surgical risk, such as the elderly or those with multiple comorbidities.

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Intrinsic and extrinsic factors, such as anatomy, age, and diet, help define the nature of the flora typical to each species of animal. factor V mutation (Factor V-Leiden) was more frequent in patients having occluded vascular reconstructions. A new method is described for performing oral fiberoptic bronchoscopy during noninvasive ventilation through the nose. Two, the alpha helix and the beta-pleated sheet, are regularly occurring structural features of soluble proteins. Several recent studies have unveiled the profound (anoikis-independent) impact of cell metabolism on the viability of ECM-detached cells. This study demonstrated an association between high LAP and hirsutism. There is little consensus on the methodology of bipolar disorder maintenance studies. Technique and diagnostic indications for anterior cervical fusion. VA and Medicare Utilization Among Dually Enrolled Veterans with Type 2 Diabetes: A Latent Class Analysis.

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An improved concept for hospital pharmacy service: Memorial Hospital of Long Beach. MiR159 and SlGAMYBs were expressed in preanthesis ovaries, mainly in meristematic tissues, including developing ovules. Progesterone inhibits apolipoprotein-mediated cellular lipid release: a putative mechanism for the decrease of high-density lipoprotein. Rather than continuing the debate, research needs to encompass new psychotherapies such as e-therapies, transdiagnostic treatments, psychotherapy component studies, and findings from neurobiology to elucidate the effective process components of psychotherapy. Knockdown of calponin 2 suppressed cell growth in gastric cancer cells.

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Compared to the traditional anonymous peer review process, open post-publication peer review provides additional opportunities -and challenges- for reviewers to judge scientific studies. The exact prognostic value of the TG/HDL-C ratio, a marker for cardiovascular events, is currently unknown among Iranians so this study sought to determine the optimal cutoff point for the TG/HDL-C ratio in predicting cardiovascular disease events in the Iranian population. In contrast to native catfish IgM, the mouse-catfish chimeric IgM showed the property of binding strongly to protein A of Staphylococcus aureus. We identify contributing H-bonds that are key to adhesion and demonstrate a specific periodic pattern of interfacial H-bond network dictated by the interface mismatch and intramolecular H-bonding. In cellular experiments, cotransfection of unhybridized pshluc2BS, Zorro LNA and pEGFPluc was also performed. Immunomodulation of human peripheral blood mononuclear cell functions by defined lipid fractions of Mycobacterium avium. Oxidative stress-mediated apoptosis induced by 20S-PPD was blocked by N-acetyl-l-cysteine pretreatment.

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On-line monitoring of large cultivations of microalgae and cyanobacteria. The concentrations and distribution of polychlorinated biphenyls were determined in water, surface sediments and fishes from the estuaries of Pearl River, PR China. Doxorubicin (DOX) and trastuzumab (TRA) are associated with cardiac dysfunction. Defects and particle motions in the nonuniform melting of a two-dimensional Coulomb cluster. Theoretical models and observational studies suggest self-organization, the formation of patterns due to ecological interactions, is critical for enhanced ecosystem resilience. Morphostructural study of the lingual papillae in the buffalo (Bubalus bubalus). Ultra-weak luminescence of serum and urine of bone tumor patients. Associations between adiposity and indicators of thyroid status in children and adolescents. Several molecules involved in gemcitabine metabolism, including human equilibrative nucleoside transporter (hENT1), deoxycytidine kinase (dCK), and ribonucleotide reductase subunit M1 (RRM1), have been investigated as predictive biomarkers of gemcitabine efficacy, mostly in pancreatic cancer.

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Impact of Structural Modification on the Photophysical Response of Benzoquinoline Fluorophores. Limonene is currently produced as a side product from the citrus juice industry, but the availability and quality are fluctuating and may be insufficient for novel bulk applications. These results, in addition to describing the distribution of actin in D. In particular, the occurrence of regulatory changes in receptors during the course of intact cell binding assays is considered, with approaches for circumventing these complications and for using intact cell assays to advantage in studying these regulatory changes. An integrated analysis of the efficacy and safety of desvenlafaxine in the treatment of major depressive disorder.

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Immunofluorescence study on semi-thin sections of tissues embedded in hydrosoluble polyepoxide. In this study, measurements of the zero shear rate viscosity of linear polyacrylamide (LPA) solutions are used to determine the LPA molecular weight before and after gel-loading. From chemical risk assessment to environmental resources management: the challenge for mining. In hearts with persistent truncus arteriosus (PTA), double outlet right ventricle (DORV), or transposition of the great arteries, rotation of the myocardial wall of the OFT is arrested or fails to initiate. Probabilities, survival and health utilities were from published studies. We studied 15 children 2 to 7 years old who had severe perennial asthma. Extraskeletal calcifications generally develop in uremic patients. Together with other forms of bias, this may have detrimental effects for patients depending on medical research for their health. This strength can yield unique benefits for HSR not available through other methods. These tumors are relatively uncommon in the genitourinary system and particularly in the penis.

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Severely injured patients presenting to four level-3 and five level-4 trauma hospitals 3 years before and 3 years after trauma system implementation. SNTSCs suppressed not only the viability of T-cells, but also the differentiation of interleukin 17 (IL-17)-secreting helper T (Th17)-cells in in vitro co-culture experiments. Animals injected with saline, buspirone (0.2 mg/kg) and propranolol (1 mg/kg) for 2 weeks were exposed to an episode of 2 hours restraint stress. Significant controversy persists in the classification of giant cell lesions of the maxillofacial skeleton. Therefore, edaravone, an antioxidant agent, might be a novel therapeutic agent which develops the new strategy for treatment of RA, and more detailed studies are required to establish the therapeutic effect of edaravone on RA in vivo.

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Secondary end points included the type and rate of complications and reoperations. Urinary Tuberculosis with Renal Failure: Challenges in Management. The pathogenesis of post kala-azar dermal leishmaniasis from the field to the molecule: does ultraviolet light (UVB) radiation play a role?. Unmasking local activity within local field potentials (LFPs) by removing distal electrical signals using independent component analysis. To assess the severity of health problems, BMI, Snellen, Strengths and Difficulties Questionnaire, and Child Behavior Checklist, scores were compared for both approaches in subgroups of children with overweight, visual disorders, or psychosocial problems. Sometimes Lipoma Arborescens can present in conjunction with inflammatory arthritis.

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Epidermal growth factor induces its dimerization and stimulates phosphorylation of intracellular tyrosine residues. All these changes are consistent with endogenous CCK, released by Intralipid, inhibiting intake independent of the concomitant slowing of gastric emptying. Lymphomatoid granulomatosis: a case report with unique clinical and histopathologic features. Chiral CdTe nanoparticles coated with cysteine self-organize around Te cores to produce helical supraparticles. There has thus been increasing discussion about how to analyze the resulting big datasets. faecalis isolates from nine acute-onset PBE cases were examined using pulsed-field gel electrophoresis of genomic DNA, plasmid isolation and pheromone response experiments. In this study, we demonstrate the potential of four pumpkin GA oxidase-encoding genes to modulate the GA plant hormone pool and alter plant stature and development imdur er dosing . NSAIDs are used throughout the World Health Organization three-step analgesic ladder, and are indicated for pain in all stages of malignancy. Furthermore, CVA-16, several strains of echoviruses and human parechovirus type 1 were unable to replicate in foetal porcine pancreatic beta-cells.

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