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Alprotame (Alprazolam)

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Alprotame is commonly used to treat anxiety and panic disorders. It falls into a category of medications called benzodiazepines. They are known to affect the central nervous system components and produce a calming effect, thus decreasing brain activity.

Other names for this medication:
Aderta, Aldip, Alprac, Alprogard, Alzep, Anilam, Anxigon, Avizolem, Besquil, Calmef, Coolam, Depsolam, Depwell, Ecsit, Erazol, Ezoprax, Fluzolam, Mebrin, Niravam, Nokzok, Parazolam, Pecalm, Pizolam, Propnix, Proprazolam, Resolin, Samitol, Somnirest, Sowel, Stresnil, Tagat, Tancalm, Tenan, Tenfree, Tenil, Tensyn, Texidep, Xanti, Zedel, Zeftra, Zoltweet

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Soma, Lioresal, Cozaar, Arimidex, Micardis, Ariclaim, Momecon, Metrovax, Sugnil, Tryline, Nemacys, Torlactone,

Also known as: Alprazolam


Alprazolam is used to relieve symptoms of anxiety, including anxiety caused by depression. It is also used to treat panic disorder in some patients.

Alprazolam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Alprotame. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Alprotame XR can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, and coma.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Alprotame dosage information

Side effects

The most common side effects associated with Alprotame are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

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Importantly, knockdown of BS69 by small interfering RNAs specifically inhibits JNK activation by LMP1 but not tumor necrosis factor alpha. For the validation of this new semi-automatic approach, CBCT scans of ten patients who underwent bimaxillary surgery were acquired pre-operatively. We next showed that 16k PRL reduced the activation of Rac1 in a concentration-dependent manner. The ion focusing and wake formation behind the dust particle are demonstrated for different ion mean free paths and the external electric fields. Moreover, tanshinone IIA can inhibit glutamate-induced apoptosis through regulation of apoptosis-related protein expression and MAPK activation, including elevation of Bcl-2 protein level, decrease in Bax and cleaved caspase-3 levels, and suppression of JNK and p38 MAPK activation. Reduced efficacy of albendazole against Ascaris lumbricoides in Rwandan schoolchildren. Technical innovations, better understanding of donor and recipient aspects, and global improvements were the reasons for time-related improved results of liver transplantation. ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading. Various findings concerning cobalt teletherapy in treatment of pelvic diffusions of carcinoma of the portio vaginalis.

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Patients with CIDP-MGUS had, on average, a more indolent course and less severe weakness than patients with CIDP-I, despite similar motor conduction studies. Glutamine is important in nitrogen transportation and the physiological control of acid-base regulation. Elliptic bulge tests are conducted on liver capsule, a fibrous connective membrane, associated with a field measurement method to assess the global geometry of the samples during the tests. A clear type-response relationship between the level of copper uptake and the type of carbon and nitrogen sources was observed. It is recommended as a part of the pre- and postoperative physical examination of patients undergoing rhinoplasty. Knock-out of IkappaBalpha, but not p65 or p50, leads to disappearance of HDAC3 in the cytoplasm, which is associated with HDAC3 enrichment in the nucleus. The number of B cells that secrete anti-TT IgG increases after immunizations in both young and old subjects, although the number in old subjects is significantly lower than in young subjects at all times except 6 months after. Case vignettes illustrate how mental health professionals can help patients obtain benefits to improve the quality of their living conditions.

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Preliminary shielding assessment for the 100 MeV proton linac (KOMAC). The effect of the new control system on hand function and dexterity was compared with those obtained with rigid orthosis and no orthosis. The sample of 656 participants had a panic disorder with or without agoraphobia, agoraphobia, social phobia, generalized anxiety disorder, major depressive disorder or dysthymia, and a subsequent remission. These cases suggest that atomoxetine may be a safe and effective treatment for ADHD in conjunction with mood stabilizers in children with BD. National data from the period 1995-2004 were extracted from the Danish Medical Birth Register and linked to the Danish National Hospital Register followed by registration of relevant data from the medical records of all the patients.

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Linear regression analysis showed significant effect of polymorphisms in genes ZKSCAN5 and ARPC1A on serum DHEAS levels in female RA patients but not in the control group. These phenotypes are not a direct result of delocalization of McpG, as this chemoreceptor does not mediate chemotaxis to any of the compounds tested and can therefore be considered a marker for general methyl-accepting chemotaxis protein (MCP) clustering. This case demonstrates that cortical dysplasia may be the underlying cause in some cases of childhood epilepsia partialis continua of the progressive type. This small peptide binds to cell surface receptors, initiating a wide diversity of physiologic responses. Description of method and effect of parasympathomimetic agents and serotonin. The authorship and fate of international health papers submitted to the American Journal of Public Health in 1989. Linear exponential smoothing models forecasted future incidence. The reduction in fast-acting cochlear compression associated with SNHL exaggerates the perceived fluctuations in intensity in amplitude-modulated sounds. Longer-acting methods of drug delivery, such as vaginal rings, may simplify use of antiretroviral medications and provide HIV-1 protection. An excision technique with permanent sections using a team of dermatopathology and surgery that carefully examines the central tumor and the surgical margins is reliable for the treatment of LM and LMM.

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Topiramate is a medication that is approved as both monotherapy and adjunctive treatment of seizure disorder in adults and adolescents. This review summarizes recent trends and advances in synthesis, manufacturing and scale - up of cocrystals. The simplest explanation involves a mechanism whereby most mutations are fixed in both strands prior to the first round of post-irradiation DNA replication. Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Reports indicate that human and canine patients with atopic dermatitis (AD) have reduced production of several skin antimicrobial peptides, but more recent data have called those results into question. Bmi-1, a putative proto-oncogene, is a core member of the polycomb gene family, which is expressed in many human tumors. The patient remains tumor free at 3 years after liver resection and currently enjoys excellent health. Additionally, we found that colour presentation did not yield better memory performance over grayscale images. High aspect ratio sharp nanotip for nanocantilever integration at CMOS compatible temperature.

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Clozapine, a powerful neuroleptic with unique clinical efficacy (and without parkinsonic side effects), has been shown to have an unusual EEG profile. The main mosquito vector for WNV, Culex pipiens, consists of two behaviourally distinct biotypes, pipiens and molestus, which can form hybrids. Neural adaptations to strength training have long been recognized, but knowledge of mechanisms remains incomplete. Radiofrequency ablation of lung metastases: factors influencing success. We report the case of a 22-month-old girl having Kabuki make-up. For each of these systems, we report a deviation of the wetting contact angle from the macroscopic value, and we discuss this effect in term of mesoscale surface heterogeneity and long-range solid-liquid interactions.

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We demonstrate in this work that Raman spectra can be obtained even for 0.01 monolayers of R6G on Si simply by spreading silver nanoparticles and/or fabricating Ag nanoparticles and nanoaggregates at the gaps and vacant sites of R6G molecules. Familial forms appear to warrant close follow up, given the apparent increased risk of malignancy. Effects of dietary zinc restriction on postprandial changes in plasma zinc. Current status and problems in the hygiene and nursing course in a high school. Inducible NOS mRNA and protein expression levels in dura and pia mater were unaffected by stress. Given the high prevalence of obesity, and growing numbers of bariatric-metabolic surgeries performed, primary care physicians increasingly encounter patients who have had, or are considering, bariatric-metabolic surgery. No statistically significant correlation was found between the occurrence of high titres of type-specific 0-antibodies to E. Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts.

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Omp2a emerges as a potential antigen candidate for serodiagnosis of human brucellosis. Deletion of neither HDA1 nor RPD3 affected the high level of white-phase expression and the low level of opaque-phase expression of the MADS box protein gene MCM1, which has been implicated in the regulation of opaque-phase-specific gene expression. Case report and review of lupus erythematosus cells in cytology fluids. In sarcoidosis patients with involvement of at least 2 organs, sleeping behaviour that includes RLS and sleep apnea should be evaluated. The identification of correlated regions requires segmenting the gene expression correlation matrix into regions of homogeneously correlated genes and assessing whether the observed local correlation is significantly higher than the background chromosomal correlation. Our results are consistent with the hypothesis of a potential role of conjugal transmission of H pylori infection in high-prevalence population groups. Although wheel running could reduce anxiety-like behaviors in both EPM and ETM, only diazepam was effective in the EPM, while fluoxetine, reboxetine, and venlafaxine were effective in the ETM. Our investigations have shown the following substantial findings: a regular increase of prealbumin, alpha1-glycoprotein, haptoglobin, hemopexin and beta2-glycoprotein, as well as a rather frequent increase of alpha 2-macroglobulin. Practical Guide to Direct New Oral Anticoagulant Use for Secondary Stroke Prevention in Atrial Fibrillation.

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Frequencies of cells stained by this antiserum correspond to the frequencies of LPS-reactive B cell precursors recently determined. The simulation and experiment results verified the double-band, wideband and polarization-independent RCS reduction by the absorptive and anti-phase gradient metasurfaces. On the early diagnosis of carcinoma of the cervix uteri in medical practice. On poolscanning of the cardiac vessels with special reference to the indium-iron ascorbic acid method. FG and Rd injections that overlapped the cardiovascular region of BST resulted in retrogradely labelled neurons throughout the amygdala.

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