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Alfacip (Calcitriol)
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Alfacip

Alfacip is a synthetic version of Vitamin D3 used to treat calcium deficiency with hypoparathyroidism and metabolic bone disease in people with chronic kidney failure.

Other names for this medication:
Actical, Admax, Alfacal, Alphadol, Apcical, Biocal, Bonestat, Calasto, Calcicare, Calcirol, Caldix, Calosto, Caltive, Caltop, Calzem, Citroj, Denscal, Dmcal, Duracal, Koncal, Minroset, Ostonex, Primacal, Rolsical, Septriol, Sorvate, Trolec

Similar Products:
Ovral, Feldene, Loxitane, Flomax, Urispas, Avasth, Metronour, Ramcet, Combiflam, Ostriol, Amracin,

Also known as: Calcitriol

Description

Generic Alfacip is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Alfacip are intestine and bone. Generic Alfacip receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Alfacip may also act on the kidney and the parathyroid glands. Generic Alfacip is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Alfacip has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Alfacip, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Alfacip in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Alfacip produces other independent beneficial effects. Alfacip is also known as Calcitriol. Generic Alfacip treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Alfacip is Calcitriol. Brand name of Generic Alfacip is Alfacip.

Dosage

This section provides information on the proper use of a number of products that contain vitamin d and related compounds. It may not be specific to Alfacip. Please read with care.

For use as a dietary supplement:

Do not take more than the recommended daily amount. Vitamin D is stored in the body, and taking too much over a period of time can cause poisoning and even death.

If you have any questions about this, check with your health care professional.

For individuals taking the oral liquid form of this dietary supplement:

This preparation should be taken by mouth even though it comes in a dropper bottle. This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.

While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health care professional may want you to follow a special diet or take a calcium supplement. Be sure to follow instructions carefully. If you are already taking a calcium supplement or any medicine containing calcium, make sure your health care professional knows.

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For alfacalcidol To treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For parenteral dosage form (injection): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 12 mcg a week. To treat diseases in which calcium is not used properly by the body: For oral dosage form (capsules): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 0.25 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day.

For calcifediol To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults, teenagers, and children over 10 years of age—At first, 300 to 350 micrograms (mcg) a week, taken in divided doses either once a day or every other day. Your doctor may change your dose if needed. Children 2 to 10 years of age—50 mcg a day. Children up to 2 years of age—20 to 50 mcg a day. To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage forms (capsules and solution): Adults, teenagers, and children—At first, 0.25 micrograms (mcg) a day. Your doctor may change your dose if needed. For parenteral dosage forms (injection): Adults and teenagers—At first, 0.5 mcg injected into a vein three times a week. Your doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For dihydrotachysterol To treat diseases in which calcium is not used properly by the body: For oral dosage forms (capsules, solution, or tablets): Adults and teenagers—At first, 100 micrograms (mcg) to 2.5 milligrams (mg) a day. Your doctor may change your dose if needed. Children—At first, 1 to 5 mg a day. Your doctor may change your dose if needed.

For doxercalciferol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—10 micrograms (mcg) three times weekly at dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For ergocalciferol The amount of vitamin D to meet normal daily recommended intakes will be different for different individuals. The following information includes only the average amounts of vitamin D. To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes: For oral dosage form (capsules): For the U.S. Adults and teenagers—5 to 10 micrograms (mcg) (200 to 400 Units) per day. Pregnant and breast-feeding females—10 mcg (400 Units) per day. Children 4 to 10 years of age—10 mcg (400 Units) per day. Children birth to 3 years of age—7.5 to 10 mcg (300 to 400 Units) per day. For Canada Adults and teenagers—2.5 to 5 mcg (100 to 200 Units) per day. Pregnant and breast-feeding females—5 to 7.5 mcg (200 to 300 Units) per day. Children 7 to 10 years of age—2.5 to 5 mcg (100 to 200 Units) per day. Children 4 to 6 years of age—5 mcg (200 Units) per day. Children birth to 3 years of age—5 to 10 mcg (200 to 400 Units) per day. To treat deficiency: Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency. To treat diseases in which calcium and phosphate are not used properly by the body: Adults and teenagers—At first, 1000 to 500,000 Units a day. The doctor may change your dose if needed. Children—At first, 1000 to 200,000 Units a day. The doctor may change your dose if needed.

For paricalcitol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—1 to 2 micrograms (mcg) one time per day or 2 to 4 mcg three times a week (not more often than every other day). The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor. For parenteral dosage form (injection): Adults—0.04 to 0.1 micrograms (mcg) per kg no more than every other day during dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Alfacip and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Alfacip are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Problems in older adults have not been reported with intake of normal daily recommended amounts. Studies have shown that older adults may have lower blood levels of vitamin D than younger adults, especially those who have little exposure to sunlight. Your health care professional may recommend that you take a vitamin supplement that contains vitamin D.

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An analysis of risk factors for death and mode-specific death after aortic valve replacement with allograft, xenograft, and mechanical valves. Initiation with a protected thiol gives, upon deprotection, thiol-terminated transporters which can be thiol-click conjugated to a variety of probes, drugs and other cargos as exemplified by the conjugation and delivery of the model probe fluorescein-maleimide and the medicinal agent paclitaxel (PTX) into cells. Treating hepatitis C virus in patients with chronic renal failure. Difficulties in interpreting the Nelson test in regard to infants. Sternal wound management after bilateral internal thoracic artery grafting: a significant detail.

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longicornis with Langat virus (LGTV), a naturally attenuated member of the TBEV serocomplex. Functional studies demonstrated that MEG3 showed positive regulation on TUNEL-positive cells and ROS level. Formation of immature neutrophil leucocytes in schizophrenic patients treated with various antipsychotic drugs: comparisons and predictions. The tobacco polypeptides activate the synthesis of defensive proteinase-inhibitor proteins in a manner similar to that of systemin, an 18-amino-acid polypeptide found in tomato plants. Immunization and symptoms of atopic disease in children: results from the International Study of Asthma and Allergies in Childhood.

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Previous studies have shown that treatment of mouse embryos with mevastatin prevents blastocyst formation, but how HMG-CoA reductase is involved in preimplantation development is unknown. The secondary endpoints were the number of MDT meetings, the number of submissions discussed or refused, outcomes in patients who underwent surgery in another center after refusal, or deferral in our MDT meeting. The correlation of leukocytic transfer with other sensitivity factors. We did not find evidence to support the existence of a genital reservoir of the types causing epidemic gonococcal conjunctivitis. Exosomes, although isolated from unfractionated culture media, were absent in highly infectious, purified virus preparations. Long-acting formulations are an important therapeutic option for non-adherent patients with schizophrenia. A decrease in optical density (O.D.) over time, indicative of cell lysis, was also observed. Attitudes toward xenotransplantation among nonhealth service workers in a hospital with a preclinical xenotransplantation program. The experience gained from this patient will be selectively used when treating the next patient with similar symptoms. Gastrointestinal (GI) symptoms are often attributed to adverse reactions to foods (ARF), but it is not always clear whether such reactions are caused by food allergy.

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Our objective was to optimize the CA technique on mammal embryos. To increase the safety of patients undergoing endoscopic investigation, pulse oximeter and oxygen supplementation should be the standard requirement in all of the endoscopic investigation rooms. Connective tissue consists of fibroblasts and extracellular matrix (ECM) with collagen and elastic fibers, glycoproteins and proteoglycans (PGs) and it is considered an important factor of the supportive structures of the genitourinary region. Computed tomography showed purulent fluid in the left kidney, and nephrectomy was performed. Patients with schizophrenia are capable of adhering to a diet and fitness program and successfully lose weight, regardless to taking typical or atypical medications. Identification of Prognostically Relevant Chromosomal Abnormalities in Routine Diagnostics of Multiple Myeloma Using Genomic Profiling. In all, 110 patients with biopsy-proven HCV (60 renal transplant recipients and 50 hemodialysis patients), determined using the METAVIR scoring system, were studied. The monthly occurrence of non-aggressive criminal acts showed a different pattern as compared with the annual rhythm of aggressive criminal acts. These latter changes can be viewed as being detrimental to cartilage function and are enhanced in osteoarthritic cartilage, resulting in aggrecan depletion and predisposing to cartilage erosion. For intensities in between, it is concluded that noisy experimental data may provide seemingly irrefutable evidence of a linear dependence on sound pressure (range II).

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Evaluation (assessment) of three tests for diagnosis of geohelmints in Colombia. Much of what is known about health disparities is based on cross-sectional measures collected at a single time point. General aspects and prevention of acute renal failure during ACE inhibitor therapy are discussed. Re: Azathioprine monotherapy for maintenance of remission in pediatric patients with autoimmune hepatitis. Nylon was selected as external reference to obtain the Raman emission independently from the laser beam power.

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Exposure of the mutant to gamma-radiation, however, induces RAD-51 foci, which suggests that the failure of RAD-51 to load is specific to meiotic (SPO-11-generated) DSBs. Data regarding hormone-related risk factors for depressive symptoms occurring in the very early postpartum period are scarce and may be of importance in identifying serious postpartum illness. Top-down proteomics for the analysis of proteolytic events - Methods, applications and perspectives. After 20 h of UV exposure, we found statistically significant parlodel dosage mims changes in at least one parameter for each lens type evaluated. Activities of pX likely relevant to hepatocyte transformation include activation of the mitogenic RAS-RAF-MAPK and JNK pathways. Thus we describe a form of glutamate receptor plasticity induced by natural spike patterns whose primary physiological function is to regulate cellular excitability. Endotension after Abdominal Aortic Aneurysm Endovascular Repair in Cirrhotic Patients. Ultrathin film deposition by liquid CO2 free meniscus coating-uniformity and morphology.

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However, a non significant excess of antigens shared in common by both parents was shown in comparison with the normal couples. These results confirm the possibility of gene amplification from thermally degraded DNA. In the Fish Intervention Studies-TEENS (FINS-TEENS) study we individually randomized 478 adolescents (14-15-year-olds) from eight secondary schools in Norway to receive school meal lunches with fatty fish or meat or n-3 supplements three times a week for 12 weeks. Aberdeen Area Indian Health Service (North Dakota, South Dakota, Iowa, and Nebraska). From grass to gas: microbiome dynamics of grass biomass acidification under mesophilic and thermophilic temperatures. Current screening recommendations for developmental dysplasia of the hip may lead to an increase in open reduction.

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Relationship between the urinary excretion mechanisms of drugs and their physicochemical properties. The present study demonstrated close association of the incidence of apoptosis with the tumor grade of TCC of the renal pelvis and ureter. CT demonstration of one or more infarcts increases the likelihood of this diagnosis. In summary, MCL cells are heterogeneous in their response to BTK or PKC inhibition, indicating the need for even more individualized targeted treatment approaches in subsets of MCL patients. Subunit structures of purified beef mitochondrial cytochrome bc1 complex from liver and heart. The concentration of serum H-FABP before discharge from hospital may be an independent predictor for critical cardiac events in DCM. Breathing pattern abnormalities with prolonged apneas occur in newborn mice that lack genes involved in the development of rhythmogenesis. The hypopigmented skin lesion disappeared within 48 h, and the infant remained stable. what is the generic name of zyrtec

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The relationship between tumour proliferative activity, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer. The finite radius of convergence of the mode-coupling expansion is found. Few studies have examined the effects of paternal and maternal history of myocardial infarction (MI), including age at MI, on cardiovascular disease (CVD) risk, particularly among women. The methods used to communicate relevant outcomes in oncology to patients will likely influence treatment decisions. The ectopic overexpression of a citrus gibberellin 20-oxidase enhances the non-13-hydroxylation pathway of gibberellin biosynthesis and induces an extremely elongated phenotype in tobacco. These chronic conditions were associated with early institutionalization and increased mortality rates.

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These findings could deepen our understanding about immunomodulatory mechanisms of croaker and shed a new light to the role of component system in teleostean immunomodulation. Integrated with the kinetic model, it is concluded that the oxidation rate of magnesium sulfite inhibited by ascorbic acid is controlled by the intrinsic chemical reaction. He responded well to extracorporeal liver dialysis (originally intended as a bridging therapy) and subsequently recovered without the need for liver transplantation. xanax overdose how much A decoy oligonucleotide encoding the heat shock element inhibited statin-induced expression of heat shock protein 70, endothelial nitric oxide synthase, and thrombomodulin. However, how the dynamic activity in OFC changes during opiate administration and withdrawal period has not been investigated. Time-course samples were also obtained from 5 of 18 PTX patients without vitamin D analogs or calcium administration. Autoinhibitory alpha2-adrenoceptors lose their activity, whereas stimulatory beta2-adrenoceptors are sensitized. Exploring e-Health usage and interest among cancer information service users: the need for personalized interactions and multiple channels remains. Practicing radiologists perform more accurately on screening compared with diagnostic MR and when evaluating masses as opposed to areas of nonmass enhancement. Though there is a statistically significant improvement after intervention, some were not cured.

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Further studies to investigate the most suitable definition of MetS for Iranian adolescents are necessary. Extensive extraction of groundwater has resulted in deterioration of the groundwater quality in the Puttalam area in the northwestern coastal zone of Sri Lanka. It is well-recognized that the failure of many chemotherapeutics arises due to an inability to induce apoptosis. Detection of human papillomavirus infection by molecular tests and its relation to colonic polyps and colorectal cancer. Myosin heavy chain synthesis was measured and found normal in all patients with myotonic dystrophy. We investigated the chronic effects of strength training on muscle hypertrophy in different regions of the elbow flexor muscles. Patients with primary duodenal adenocaricinoma, who are medically fit to undergo surgery, should be given the option of aggressive resection. In non-keratinzed normal mucosa, CK19 was detected in the basal cell layer, while in dysplasias (diagnosed in H and E stained sections, mild-severe) stained strongly for CK 19 in the basal and supra basal cell layers indicating layer specificity for CK 19 expression.

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Adequate biomaterials for tissue engineering bone and replacement of bone in clinical settings are still being developed. Nutrient limitation is one of the most common forms of stress encountered by microorganisms in the environment. The purpose of this work is to evaluate the dosimetric parameters of a hypothetical (153)Gd source for use in brachytherapy and comparison of the dosimetric parameters with those of (192)Ir and (125)I sources. These changes were accompanied by a decrease in functional activity of erythropoietic precursors and secretion of erythropoietically active humoral factors by bone marrow myelokaryocytes. From molecules to macrostructures: recent development of bioinspired hard tissue repair. Purposes of the methods were often not specifically indicated, methods for subgroup analysis for safety purposes were almost absent and a multitude of diverse methods were developed for purpose (1). Cold sodium atoms are trapped in a far-detuned standing wave of light that is accelerated for a controlled duration. The twelve patients consisted on eight men and four women with an average age of 25.8 years. Because this was an investigation to determine the percentage of children who could complete the Randot test, children who failed a vision screening modified from the Modified Clinical Technique were excluded to minimize confounding factors (ie, a lack of measurable stereopsis due to vision problems rather than inability to understand the test). Probing the relationship between external and internal human exposure of organophosphate flame retardants using pharmacokinetic modelling.

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Effect of prepubertal gonadectomy and sex steroid treatment on the growth and lymphocyte populations of the rat thymus. A 3D FE model containing one Frialit-2 implant splinted to the mandibular second premolar was constructed. The clinical profile shows similarities in secondary fibrillation. Although the majority of biomarker studies in heart failure focus on their prognostic value, the clinical applicability of prognostication in heart failure needs to be established. Reversible activation defect of the platelet glycoprotein IIb-IIIa what drug classification is atarax complex in patients with uremia. In particular, we identified an AP-1 regulated transcriptional network in dlPFC neurons associated with cocaine use disorder that contains several differentially expressed hub genes. Clinical implications of hemodialysis membrane biocompatibility. Second peak of plasma diazepam concentration and enterogastric circulation.

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