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Aldactone (Spironolactone)

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Aldactone is a prescription medicine used to treat the symptoms of high blood pressure (hypertension), low potassium levels (hypokalemia) and heart failure. Aldactone may be used alone or with other medications. Aldactone belongs to a class of drugs called Aldosterone Antagonists, Selective, Diuretics, Potassium-Sparing.

Other names for this medication:
Aldostix, Amifru, Aquamide, Dyamide, Dytor, Fruselac, Frusis, Lactone, Lasilactone, Metolactone, Spilactone, Spiromide, Spironolactone, Spirotic, Torlactone, Tormax, Torsid, Zator

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Also known as: Spironolactone


Aldactone (spironolactone) is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.

Aldactone is used to treat heart failure, high blood pressure (hypertension), or hypokalemia (low potassium levels in the blood).

Aldactone also treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome.

Aldactone is also used to diagnose or treat a condition in which you have too much aldosterone in your body. Aldosterone is a hormone produced by your adrenal glands to help regulate the salt and water balance in your body.


Usual Adult Dose of Aldactone for Edema:

25 to 200 mg orally per day in single or divided doses

Usual Adult Dose of Aldactone for Hypertension:

Initial dose: 50 to 100 mg orally per day in single or divided doses

Usual Adult Dose for Congestive Heart Failure:

Initial dose: 25 mg orally once a day assuming serum potassium is less than or equal to 5 mEq/L and serum creatinine is less than or equal to 2.5 mg/dL

Usual Adult Dose for Primary Hyperaldosteronism:

Diagnostic dose:

Usual Adult Dose for Hypokalemia:

25 to 100 mg orally per day

Detailed Aldactone dosage information


If you overdose Generic Aldactone and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Aldactone overdosage: diarrhea, vomiting, nausea, red skin rash, loss of energy, slow heartbeat, weakness in legs, feeling drowsy, confusion.


Store below 25 degrees C (77 degrees F). Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Aldactone are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Generic Aldactone if you are allergic to Generic Aldactone components. Do not take Generic Aldactone if you're pregnant or you plan to have a baby, or you are a nursing mother. Generic Aldactone can harm your baby. Do not take Generic Aldactone if you are taking potassium-sparing diuretics (such as Aldactazide, amiloride (Moduretic, Midamor)), triamterene (such as Maxzide, Dyazide, Dyrenium)). Be careful using Generic Aldactone if you take inhibitors (enalapril (such as Vasotec), fosinopril (such as Monopril), captopril (such as Capoten), benazepril (such as Lotensin), lisinopril (such as Zestril, Prinivil), quinapril (such as Accupril), moexipril (such as Univasc), ramipril (such as Altace), trandolapril (such as Mavik)); oral steroids (dexamethasone (such as Decadron, Dexone), prednisone (such as Deltasone), methylprednisolone (such as Medrol)); aspirin and other nonsteroidal anti-inflammatory medicines (naproxen (such as Aleve, Naprosyn), ibuprofen (such as Advil, Motrin), indomethacin (such as Indocin)); diuretics; barbiturates, phenobarbital; digoxin (such as Digitek, Lanoxicaps, Lanoxin)); high blood pressure medicines, lithium (such as Lithobid, Eskalith); perindopril (such as Aceon).It can be dangerous to use Aldactone if you suffer from or have a history of liver disease, kidney disease, potassium high levels in your blood, problems with urination. Be careful with this drug if you are going to have a surgery. Avoid food with high level of salt. Avoid dehydration. Avoid medicines which cause lightheadedness. You should be careful when you are driving or operating machinery. Do not stop taking Generic Aldactone suddenly.

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Blood group frequencies of immigrant and indigenous populations from South East England. Having a human interface improves communication among physicians, patients, nurses, and families. A comparison between the frequency of Hb S heterozygotes in blood donors, outpatients, and inpatients of a general hospital carried out at the Maputo Central Hospital, Mozambique, where Plasmodium falciparum malaria is endemic, showed a statistically significant lower percentage of Hb S heterozygotes in the inpatient group. Effects of age on the quality of care provided to older patients with acute myocardial infarction. The present work aimed to study the impact of amino acids on S6K1 activity in quail muscle (QM7) myoblasts. The intravenous data were obtained from a previous study of the pharmacokinetics of serum digoxin and its inotropic response (derived from systolic intervals) in 12 normal male volunteers.

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Analysis of the tet repressor-operator interactions using the uracil-DNA glycosylase footprinting system. A series of anatomic dissections defined the likely site of injury to be at the junction of the vocal process of the arytenoid cartilage and the membranous true vocal cord approximately 6 to 10 mm below the level of the cord. At the onset of XCI, deleting Xite downregulates Tsix in cis and skews XCI ratios, suggesting that Xite promotes Tsix persistence on the active X. It usually occurs as a result of catheter migration, omental or small bowel entrapment, or fibrin clots. Analysis of health plan disenrollment by Medicaid clients indicated that the most common reason was loss of Medicaid eligibility. Epileptic drop attacks in partial epilepsy: clinical features, evolution, and prognosis. We examined the reversibility of the changes in (ultra)structure and gap junctions. The technical details required in performing these procedures and the developmental anatomy of this and other major venous anomalies are discussed. The effects of the presence of metal irises on guided-mode propagation through a symmetrical three-layer slab waveguide are examined by using the integral equation method. However, titanium 6-4 alloy was found to be especially susceptible to abrasive wear by particles of acrylic cement.

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Is there a relationship between the acoustic occlusion effect and the sensation of occlusion?. During this process, prenatal myogenesis is recapitulated to a large extent, both morphologically and molecularly. The evaluated protocol allowed a reliable calculation of the hepatic venous draining areas and led to a change in the hepatic venous reconstruction strategy at our institution. A 49-year-old man with hypopituitarism, multifocal neurologic defects, and an intracranial mass. After administration of 1,110 MBq (30 mCi) of (11)C-acetate, whole-body PET images were obtained.

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We generated Rnaseh1(-/-) mice to investigate the role of RNase H1 in mammals and observed developmental arrest at E8.5 in null embryos. A pilot study involving therapeutic facilities in Ontario has suggested that a large-scale quality improvement effort could be undertaken in these facilities and rigorously evaluated. Introduction and selection of new poplar clones in shelterbelts/windbreaks in northern Liaoning. The craniofacial, neurological, cardiac, pulmonary, visceral, and extremity anomalies are discussed with special emphasis on hand anomalies. There were 7 patients with isolated GHD and 14 with multiple pituitary hormone deficiencies. Impact of a cultural belief about ghost month on delivery mode in Taiwan.

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Examining rates of comorbid personality disorder in broad-based community samples of bipolar spectrum patients would further clarify the linkage between these sets of disorders. Therefore, the present findings may contribute to the recognition of intratumoral hemodynamics. The procedure is based on horizontal ultrathin-layer multi-zonal (HUME) electrophoresis of PCR fragments in polyacrylamide gels followed by silver staining. A comparative study of surgical suture materials and closure techniques. However, although nNOS-immunoreactive terminals were frequently evident in the NTS, none were vagal afferent in origin. To identify phosphotyrosine-containing proteins essential for maintaining the transformed state, we studied the tyrosine phosphorylation profile of temperature-sensitive mutant of Rous sarcoma virus, tsNY68, infected cells (68N7). Depressed individuals and controls were scanned while they attempted to voluntarily down-regulate sad feelings. We report here a case of this syndrome associated with membranoproliferative glomerulonephritis. Moreover, by means of FTA-ABS-IgM and 19 S-IgM-FTA-ABS-test valuable diagnostic additional informations (early diagnosis of the infection, L.

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Multivariate techniques were used to develop and prospectively test a model to predict infection. Reversed-phase chromatography was carried out on octadecylsilica as the stationary phase with graded mixtures of acetonitrile or methanol-acetonitrile and phosphate buffer pH 2.4 as the mobile phase. Modification of guanine bases by nucleoside phosphoramidite reagents during the solid phase synthesis of oligonucleotides. A single-radial haemolysis technique for measurement of antibody to influenza virus neuraminidase in equine sera. In the Bragg case, an asymmetric broadening of the reflectivity profile leads to strong distortions of the near-edge fine structure and lioresal tab to a reduction in spectral resolution. The impact of gender and pregnancy on antiretroviral therapy for HIV: pharmacokinetic and disease-related differences. Ultrastructure of teichoic acid-deficient and other mutants of staphylococci.

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Antibody response in school children to live rubella vaccine (Cendehill strain). Follow-up continued until worsening of hip pain with Harris hip score of less than 70 points or surgery. Almost all bone, brain, and bladder cancer deaths registered were within 3 km of the 3 complexes. In contrast, antinociception was not observed in 20 day old rats after a 10 min swim-stress. The expressed antigens showed low background levels, high specificity and sensitivity in ELISA and AGID. Periodic transitions from a single-peaked Gaussianlike intensity distribution to a double-peaked intensity distribution were observed. We used a state and year-fixed effects approach to measure the effect of parity.

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A visibly transparent sample is irradiated in a spatially nonuniform manner with pulsed microwaves, and the spatial variation in temperature increase measured by detecting the phase chirp impressed on a single-frequency He-Ne laser beam passing through the heated region. Microangiographic studies of experimental erosive synovitis in rats. The degree of this protein conjugate formation correlates inversely with the magnitude of the acetylation potential depending on the availability of free non-acetylated aminoaromates. Sea buckthorn decreased and delayed the insulin response and improved glycaemic profile compared with control. It was found to be superior to the other models in that it fitted all the data sets successfully. Respiratory motion managed CTs and, particularly, retrospective 4D CTs are proving to be useful for measuring soft tissue motion, identifying patients who could benefit from gated radiotherapy, and evaluating the effects of respiratory motion during radiotherapy. Studies on oncogene and its products of human nasopharyngeal carcinoma. We propose a model in which multiple Vps4 motrin kids dosing hexamers (four or more) draw together several ESCRT-III filaments. Diagnosis at birth improves survival of children with sickle cell anemia. The structural (dipolar) relaxation is shown to be a very rapid (subnanosecond) process.

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To study the expression of heme oxygenase-1 (HO-1) in dental pulp tissue and to find out the relationship of distribution and function of HO-1. We subsequently combined our first and second data sets in an attempt to enhance the evidence for linkages in a larger sample size. Multiple wells allowed experimental and control observations on the same vascular segments. Besides rulide tablet 150 mg several other advantages, aortic valve replacement with a pulmonary autograft may result in improved hemodynamic characteristics compared to other valve replacement procedures. Co-localization of G protein pathway signalling molecules probably contribute to both spatial and temporal regulation of signal transduction. The authors analyzed data from the Commonwealth Fund Survey of Parents With Young Children, a national sample of 2,017 parents with children younger than 3.

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Surveillance of intravenous catheter-related infections among home care clients. Monitoring of heart rate and intra-arterial blood pressure during cataplexy in humans shows a decrease in heart rate and an increase in blood pressure with onset of cataplexy, but the change in heart rate is secondary to the change in blood pressure. Peak serum concentrations of amphotericin B, given as ABCD, are lower, AUC0-infinity similar and half-life longer than deoxycholate amphotericin B. Studies consistently identify substance treatment populations as more likely to die prematurely compared with age-matched general population, with mortality risk higher out-of-treatment than in-treatment. Neither cyclooxygenase inhibitor nor 5-lipoxygenase inhibitor could block the growth-promoting ability of linoleic acid. It is compared with other implant materials and discussed in terms of host tissue reactions that may occur in joint replacement procedures. We report a case of osteoclastoma of the distal radius originally treated by curettage, then by resection and bone replacement. These effects were more pronounced when therapy was self-initiated by patients early on during a recurrence or during the prodromal period.

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It is shown that the measured contact angles are in good accordance with those obtained on flat surfaces. These results indicate that interferon seems to modulate the retinoic acid system. To ascertain the influence of volume of noncancerous prostatic tissue and zone of cancer of origin on the serum prostate-specific antigen (PSA) level to predict tumor volume and pathologic stage in men with clinically organ-confined disease. Induction of cytochromes P450 2B and 2E1 in rat liver by isomeric picoline N-oxides. This longitudinal study confirms the association between autoimmune thyroid dysfunction adalat 10 mg sublingual and type 1 diabetes. Risk factors and early diagnosis of biliary tract diseases in children. In large areas, most epidermal layers were lost exposing stratum basale or even dermis.

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This approach consequently holds great promise for application in inexpensive portable chip-based CE devices. Ventilation-perfusion scanning is the pivotal test for PE in pregnancy, and need not expose the fetus to excess radiation. A cause-effect relationship was suggested by the demonstration of antibodies against halothane-altered hepatocyte membrane components. Ventricular fibrillation induced by a fixed rate pacemaker implanted for 20 months. Separation of the regenerating liver into its constituent cell types, followed by RNA extraction and reprobing, revealed that increased TGF beta gene transcripts were confined to the enriched endothelial-cell population and not the hepatocytes. Effect of combined heat, ozonation and ultraviolet irradiation (VasoCare) on heat shock protein expression by peripheral blood leukocyte populations. TH tissue concentration and content were precisely determined along the caudorostral extent of the LC within the previously (Bezin et al., 1994) defined spaces delimited by the TH-containing perikarya. Comparative effects of calcipotriol solution (50 micrograms/ml) and betamethasone 17-valerate solution (1 mg/ml) in the treatment of scalp psoriasis.

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Morphologic and mucin histochemical analysis of transitional zones in advanced ulcerated colorectal carcinomas: potential prognostic indicators. Dose-dependent influence of commercial garlic (Allium sativum) on rats fed cholesterol-containing diet. T2 relaxation times were measured by using a spin echo sequence. To assess the efficacy and tolerance of fluconazole (150 mg oral dose, once a week) in the prevention of recurrent oropharyngeal candidiasis in patients with moderate to severe human immunodeficiency virus (HIV) infection. Common anions present in natural waters and humic acid were evaluated for their effects on NO3(-) hydrogenation over a bimetallic supported catalyst (Pd-Cu/gamma-Al2O3). The purpose of this study was to evaluate changes in the left ventricular performance using Doppler index of myocardial performance (sum of isovolumic contractile and relaxation times divided by left ventricular ejection time) and left ventricular remodelling after PTSMA for HOCM. Clustergrammer enables producing interactive web based visualizations for the analysis of diverse biological data. Understanding the pathogenesis of periodontitis: a century of discovery. No direct binding of monoglucosylated ribonuclease B or monoglucosylated glycans to ERp57 could be detected, but we show that ERp57 interacts directly with calnexin.

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