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Adalat (Nifedipine)

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Adalat is used to treat hypertension (high blood pressure) and angina (chest pain). Adalat is in a class of drugs called calcium channel blockers. Adalat relaxes (widens) your blood vessels (veins and arteries), which makes it easier for the heart to pump and reduces its workload.

Other names for this medication:
Adefin, Afeditab, Calcigard, Cardifen, Citilat, Conetrin, Coracten, Cordaflex, Duranifin, Fedip, Herlat, Hypan, Macorel, Nelapine, Nidilat, Nidipine, Nifecardia, Nifeclair, Nifedel, Nifedine, Nifedipin, Nifical, Nilol, Nipidin, Oxcord, Tenif, Tredalat, Valni, Viscard

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Also known as: Nifedipine


Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Adalat. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.


If you overdose Adalat and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of nifedipine in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems which may require caution and an adjustment in the dose for patients receiving nifedipine.

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Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination. An in vitro model of SCI demonstrated that sFasR administration decreases cell death as assessed by propidium iodide fluorescence. This procedure is simple, reproducible and is suggested as an integral part of automated diagnostic systems based on the use of laboratory work stations for DNA isolation, preparation of PCR reactions and analysis of PCR products. The aim of this study is to identify cavity as clinical subentity in squamous cell lung cancer (SqCLC) patients. Healing of osteotomy sites grafted with mismatched bone occurred by ingrowth of host periosteal and endosteal new bone. Progressive home care agencies see this as an opportunity to become leaders. The generator is connected (proper connection, was confirmed via radio frequency programming), and implanted subcutaneously. To determine if physical examination (PE) of the posterior pelvis in awake and alert trauma patients with known pelvic ring injuries can accurately predict a potentially unstable posterior ring injury and guide the use of computed tomography (CT) more effectively. Serum Ca(I) concentration showed a significant decrease by 14 days of frozen storage (-10 degrees C). The rates of succinimide formation of the asparaginyl peptides were found to be 13.1-35.6 times faster than those of the aspartyl peptides.

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In this study we showed that intravesical oxybutynin has a direct anesthetic effect within the bladder wall. Additionally, Eck coimmunoprecipitated with p85 in ligand activated cells confirming their interaction in vivo. Endothelial cell adhesion molecules (ECAMs) are felt to play an important role in ischemia/reperfusion (I/R) injury by causing adhesion of leukocytes to endothelial cells. Remarkably, in a correlation matrix of 18 electrophysiological and 6 morphological measures, only one morphological characteristic was predictive of intrinsic excitability: neurons with more spines had a significantly slower basal firing rate. Efficacy and safety of alendronate and risedronate for postmenopausal osteoporosis. These points can only produce false matches, and have no information about binocular disparities.

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Statistic method for determining the fusion-recombination of cellulase genome. Summation of the intermolecular H...H and H...C interaction energies makes it possible to reproduce the experimental sublimation enthalpy value with high accuracy. In multiple linear regression analyses well-being was negatively associated with high levels of activity limitation and participation restriction. Experimental studies and clinical experiences with bone plate osteosynthesis in fractures of the edentulous mandible. Alloplasty with prosthetic graft (marlex net, dacron, mersilene, etc.) represents an undoubted progress in the surgical treatment of inguinal hernia. Rhizosphere characteristics of indigenously growing nickel hyperaccumulator and excluder plants on serpentine soil. Structure and macromolecular properties of cervical mucus glycoproteins.

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Androgen ablative therapy may give prolonged remissions, especially in patients with previously untreated tumours. We developed the technique of microexplosion for the destruction of bladder stones and have used it since 1981 with good results. Anterior open bite--cephalometric evaluation of the dental pattern. Hepatitis C virus (HCV) encodes two putative virion glycoproteins (E1 and E2) which are released from the polyprotein by signal peptidase cleavage. Adenovirus infection is a recognized complication following haematopoietic stem cell transplantation. Northern blot analysis revealed the presence of 2 species of messenger RNA of sizes 5.1 kb and 4.5 kb.

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CT studies on the morphological changes of the brain in schizophrenics. CD23 gene is overexpressed and abnormally regulated in the most frequent adult leukemic disorder, B chronic lymphocytic leukemia (B-CLL). If the odorous substance, ethyl n-butyrate, in concentrations high enough to saturate the receptor system, is present in the nasal cavity before and during a brief exposure to N-ethylmaleimide, the nose, after a wash and a recovery period, responds in nearly normal fashion to vapors of ethyl n-butyrate. After the first SET and during the whole experimental period, a group of 6 horses received a probiotic (Bioracing) once a day while a group of 5 horses received a placebo. Two women with endometrial cancer and precancerous lesion treated with medroxyprogesterone are presented. Only histamine and some amino acids affect TRH-induced TSH secretion. Both in normal hearts and in hearts subject to chronic right ventricular pressure overload, acute left ventricular unloading decreases right ventricular contractility. Only one other relapse was seen--in a patient given a transplant during a third remission.

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It is proposed that kinin causes an increase in calcium influx at the basolateral pole of the tissue. In the early stages of NPH, when the serum creatinine values were between 134 and 370 micromol/l, the corticomedullary differentiation was weak in 6 patients, the echogenicity of the kidney parenchyma was equal to or greater than that of the liver in 5 patients, and 6 patients had developed renal cysts. The p38 mitogen-activated protein kinase regulates interleukin-1beta-induced IL-8 expression via an effect on the IL-8 promoter in intestinal epithelial cells. X-linked cutaneous amyloidosis: further clinical and pathological observations. Antiviral activity and other biological properties of two groups of polycyclic peptides are discussed. Diagnostic Cytology Towards the 21st Century: An International Expert Conference and Tutorial. In addition, we investigated the effects of pentoxifylline (PTX) on AAP-induced vascular congestion and on hepatic necrosis as evaluated histologically and by measurement of plasma transaminase activities. Comparison of the levels of quality of inpatient care delivered by pediatrics residents and by private, community pediatricians at one hospital.

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Age and physiological adjustment to continuous, graded treadmill exercise. Our study reveals a more complex relationship between longevity and fitness in large mammals than the simple increase of the number of reproductive attempts when living longer. General principles of clinical pharmacology and pharmacotherapy (a review of the literature). Intracellular pH was approximately 7.1 and did not change with brain maturation. Therefore, this examination can be helpful in deciding whether or not surgery is necessary. Growth of tumours in congenitally athymic nude rats resulted in reduction of observed metastases. Enhanced PKC activity is often found in cancer cells that show marked invasive and/or metastatic potential. However, it may start insidiously without a history of thyroid disease and without clinical signs of hyperthyroidism.

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Types of interferons detected in cerebrospinal fluid from patients with viral infections of the central nervous system. The prevalence of depressive symptoms was similar in patients with LB compared to patients with no evidence of infection. HUME gels can be prepared rapidly using a simple procedure called the flap technique. The effects of carrageenan and trypan blue on the expression of adoptive immunity to the syngeneic guinea pig line 10 hepatoma were investigated. Adjacent muscles are not always available to rotate for coverage, due to unacceptable functional loss, or injury to the principal vascular pedicle. Synthesis, analysis and application of specifically deuterated lipids.

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The concentrations of DA, DOPAC and HVA remained unchanged in the SN and VTA of both young and old rats after MPTP treatment. Two MTHFR polymorphisms, C677T and A1298C, have been associated with reduced enzyme activity and C677T with altered distribution of intracellular folate metabolites. Contiguous arrangements of two to three chlamydospores occurred in a clinical isolate of Candida albicans. Our study is the first prospective evaluation of body weight and composition in women undergoing surgery and chemotherapy for ovarian cancer. The significance of these microscopic findings for therapeutic strategy and prognosis should be determined by long-term follow-up. Fermentation of trehalose and lactose, aesculin hydrolysis together with production of beta-D-glucuronidase and alpha-D-galactosidase allowed the demonstration of nine different biotypes. Acute renal failure most likely was secondary to the nephrotoxic effect of captopril on chronically hypoperfused kidneys. We have found that many injuries can occur in a cross-country ski race, given specific race conditions. The self-organizing maps we constructed have several important characteristics. Healing of esophageal anastomoses performed with the biofragmentable anastomosis ring versus the end-to-end anastomosis stapler: comparative experimental study in dogs.

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In vitro separation of embryonic chick skeletal muscle myoblasts and fibroblasts: comparison of their characteristics. Based on histochemical staining of beta-glucuronidase (GUS) activities in the transgenic Arabidopsis plants harboring promoter::GUS constructs, AtSFH3 transcription was first detected in the stigma papillae of the flowers at stage 11, and then in the pollen grains before and after fertilization. Tn5431, a new transposable element composed of Tn1721- and Tn3-like genes. We used the same cell line to study the mechanism via which PTHrP upregulates integrin expression. Cell mediated immunity was assessed on the basis of total lymphocytes (TL), total T lymphocytes (TTL) counts, delayed skin test responses and in vitro leucocyte migration inhibition test (LIF) production in 25 patients with SSPE, classified according to the clinical stages of the disease. Interaction of tRNAPhe and tRNAVal with aminoacyl-tRNA synthetases. The potential for drug interactions is a concern to all dentists. WSSV-responsive gene expression under the influence of PmVRP15 suppression.

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The size, sign, and profile of induced circular dichroism (CD) features in the Soret region are reliable indicators of the binding modes of porphyrins and metalloporphyrins to DNA. Predisposing factors are damaged mucosal barriers due to chemotherapy, protracted periods of neutropenia, and prolonged use of antibiotics and steroids. This risk should be taken into account when planning a new pregnancy. Kallmann syndrome (KS) is a rare, congenital disorder combining hypogonadotropic hypogonadism (HH) due to GnRH-deficiency with anosmia. Principles of selection, diagnosis and treatment of patients with vasorenal hypertension and ischemic heart disease at a surgical department.

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Potential role for type II receptor in regulation of IL-1 responses. Simple and complex antibody reactions in radioimmunoassay and the prediction of assay characteristics. Adolescent personality factors in self-ratings and peer nominations and their prediction of peer acceptance and peer rejection. Letter: Haemophilus influenza apparently resistant to trimethoprim. Combined spatial and temporal imaging of brain activity during visual selective attention in humans. Myeloperoxidase, an index of myocardial nizoral london drugs leukocyte accumulation, was similar in the left anterior descending and circumflex coronary regions. Prevalence odds ratios explain the association of self-reported disease on increasing weight status category using body mass index. Role of the clinical examination in the diagnosis of facial asymmetry. Nicked CRM197 is about 50 times more effective than intact CRM197 in inhibiting the action of diphtheria toxin on sensitive cells, as shown by inhibition of diphtheria toxin cytotoxicity or inhibition of binding of 125I-diphtheria toxin.

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Each subunit was independently damaged by radiation whether or not they were bound by disulfide bridges to other subunits, demonstrating that in IgG radiation-deposited energy did not travel across disulfide bonds. Further research is necessary to examine the effectiveness of improving detection on subsequent prognosis of older patients with delirium. In the mature organism, receptor signaling is controlled through the processes of desensitization and down-regulation. Data on size, proxy measures of performance and merger intentions for 71 organisations were extracted from telephone and mail surveys of primary care groups and trusts (PCG/Ts). Biosynthesis of 5 -cholestan-3 -ol in cerebrotendinous xanthomatosis. General considerations and strategic planning are explained and illustrated by three clinical cases.

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To determine whether bronchoalveolar lavage fluid levels of the N-terminal peptide of type III procollagen (procollagen III) are increased in patients with the adult respiratory distress syndrome and, if so, whether increased procollagen III levels in lavage fluid are associated with increased fatality rates. Full-length FHOD1 co-localized with filamentous actin at cell peripheries. Tempol prevents harmful effects of remote ischemia reperfusion injury on healing of experimental colonic anastomoses. The approach enabled analysis of ammonia oxidiser enrichments at an early stage and without the requirement for isolation of pure cultures, significantly reducing the time required and facilitating quantitative assessment of relatedness of strains. The variability amongst strains in response to antibiotic exposure suggests that either the mechanisms of resistance to phagocytosis, or its regulation, may be different amongst different strains of E. In eight animals kept anesthetized with sodium pentobarbiturate, leptazol (200 mg/ml) was applied bilaterally (20 microliter on each side) to a small area of the rostral portion of medulla oblongata while blood pressure, respiration, the electrocorticogram from the sigmoid gyri, the nictitating membrane and the pupil width were monitored. Among these antibiotics, a complex called 104A, which showed the more interesting antifungal activity, was selected and purified by reverse-phase high-pressure liquid chromatography. The expected 267-bp DNA fragment was amplified from respiratory tissue of frozen, formalin-fixed, and paraffin-embedded samples from experimentally and naturally infected rats and mice. We also analyzed complexes containing MHC proteins and US2, US3, US11, or US3/US2 chimeras for the presence of cdc48/p97 ATPase, a protein that xanax dosage canine anxiety binds polyubiquitinated proteins and likely functions in the extraction of substrates from the ER membrane before the substrates meet proteasomes.

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The translated scale preserved substantial inter-rater reliability. The occurrence of SIDS is rare during the first month of life, increases to a peak between 2 and 4 months old, and then declines. It is recommended that traction be abandoned except in unusual circumstances. Relationship between IgG1 levels and airway responses in guinea pigs actively and passively sensitized to hexahydrophthalic anhydride. Serotyping, HS antigen and HL antigen, was performed on 105 Campylobacter jejuni/coli isolates from the same number of consequtive patients seeking medical attention for diarrhoea. Significant MEP amplitude facilitation occurred only in right APB, during the ON phase of motor imagery of the right hand and both hands. The evolution of two-dimensional neural network models with rank one connecting matrices and saturated linear transfer functions is dynamically equivalent to that of piecewise linear maps on an interval. We investigated the relationship between histamine and muscarinic cholinergic neurons in central nervous system (CNS)-mediated glucose regulation in anesthetized fed rats. PCR analyses with primers specific for plastid, mitochondrial and nuclear genes reveal an impressive purity of such plastid DNA fractions at a detection limit of less than one wild-type plastid chromosome copy per ten transplastomic cells. What are the clinical determinants of early energy expenditure in critically injured adults?.

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The tolerance of Q328C to ethanol and acid also increased when compared with that of the original enzyme. These dramatic changes in plasma lipoprotein concentrations during the neonatal period can best be explained by the effect of feeding. The N-terminal sequences of the MMP-3, -12, -13, and -20 processed 80kDa Ln-5 gamma2x-chains were identical whereas the N-terminus of the 80kDa(MMP-8) Ln-5 gamma2x-chain was not. This association appears to be a new, distinct neurocutaneous syndrome. In hepatocytes, only annexin VI is found to be concentrated within the microvilli in the bile canaliculi, on the inner face of the sinusoidal cell surface, particularly in the space of Disse, and all along the plasma membrane. Lymphocytes in patients with variable immunodeficiency can provera 10 mg cause miscarriage and panhypogammaglobulinemia.

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The SO and duodenum in anaesthetized rabbits were prepared with perfused catheters and bipolar electrodes. The procedure is based on measuring conductivity in the zones of lowered resistance on the scrotum skin and over the prostate at the background of a provocative tuberculin test performed with apparatus Elektronika-Elita-4M. Current methods that examine the exons and their flanking regions of the FECH gene fail to identify mutations in about one in seven of families with EPP. Strain-rate imaging during dobutamine stress echocardiography provides objective evidence of inducible ischemia. Rasmussen encephalitis (RE) is a rare devastating disease of childhood causing progressive neurological deficits and intractable seizures, typically affecting one hemisphere. Autoimmunity as a factor in recurrent vaginal cozaar medication cost candidosis and the minor vestibular gland syndrome. Thus, cultured cells that overexpress P-glycoprotein have the potential to develop some level of cross-resistance to all three topoisomerase I inhibitors currently in the clinic.

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A 0.1-0.3 min of arc sensitivity could be reached, using a vernier method. A positive correlation was obtained among the location of the venous angioma, the decreased perfusion area on SPECT images, and the electroencephalographic focus. Intraoperative electroneurography during decompression of the median nerve in the carpal tunnel. Partial responses were observed in 35 patients (3 myeloma, 7 breast, 6 prostate, 4 melanoma, 1 renal, 2 astrocytoma, 3 ovarian, 4 head and neck). The three training methods compared in this study were provision of a pamphlet describing rhinocort medicine how to do BSE, having women view a videotape depicting proper performance of BSE, and having women practice doing BSE on a life-like breast model. Perfusion cell culture is different to static cell culture: In perfusion culture, steady state concentrations of nutrients and metabolites can be achieved. With the patient under general anesthesia a single incision was made from the ureteral orifice to the verumontanum and out to fat using holmium:YAG laser energy transmitted through a 400 nm. This class of illnesses frequently involves the skin and respiratory tract because of the ease with which indoor environmental contaminants come in contact with these tissues. A limitation for proteomics research in this type of clinical sample is the amount of viable protein that can be obtained from fixed tissues. What Is New in Cesarean Delivery?: Best Articles From the Past Year.

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The current clinical treatment guideline of this disease recommends a variety of options with oral western medicines, such as aminosalicylic acids, glucocorticosteroids, and immunosuppressors. This is an area where infection with Schistosoma haematobium, causing urogenital schistosomiasis, is common but little is yet known about transmission of the disease. Their synthesis begins in the endoplasmic reticulum and is completed in the Golgi apparatus. In the CT-scan of the skull enlarged ventricles were demonstrated. A new statin, rosuvastatin, produces greater increases in HDL cholesterol than atorvastatin, but its effect on HDL particle distribution is yet to be determined. Maximal free radical generation also occurred 2 days earlier and was quantitatively greater in rats infected with 6000 L3. This could justify recommending SLIT for the preventive treatment of perennial conjunctivitis caused by house dust mites. Combined therapy management for patients with thrombolytic thrombocytopenic purpura. Interval laparoscopic appendectomy for appendicitis complicated by pylephlebitis.

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(ii) Nicking of plasmid DNA occurs via oxidants: and is prevented by antioxidants. The absence of brain-specific link protein Bral2 in perineuronal nets hampers auditory temporal resolution and neural adaptation in mice. The results showed that there were significant differences of tolerant indices to P deficiency in the test rice genotypes. A cross-section study design in which participants with elbow flexor spasticity and capable of providing written informed consent were recruited. Antemortem radiographic examination of the abdomen failed to visualize the calcification in the liver. Changes in waist and hip circumferences and WHR accompanying changes in weight over 5 years were examined in 3,753 black and white men and women initially ages 18-30. Our results confirm that monomers of P6G easily undergo relative rotations within the dimer, but we found new conformations of the R6G dimer at longer simulation times. The hD52 gene was originally identified through its elevated expression level in human breast carcinoma.

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Role of ribosomal subunits in eukaryotic protein chain initiation. However, in these two boys bromocriptine has proved effective in controlling the PRL/GH oversecretion. Polymorphisms and platelet genotyping: the shape of things to come. We describe a new PCR test (Penter RT-PCR) that recognizes all 64 prototypes of enterovirus. When surgical clipping is not safely feasible, percutaneous methods of embolization of the aneurysm can be visual or life saving. Their personal patient evaluation increases assistance with DX and teaching points. The humoral immune response of the mouse to certain antigens is characterized by the dominant expression of a single or limited number of related, immunoglobulin variable region (V) structures by antibody-secreting lymphocytes. The discriminant analysis of menopausal and personality variables classified the women equally into the group with complaints compared to the control group. Metastatic meningioma: hemangiopericytoma or angioblastic meningioma?. These variable regions are predicted to be surface-exposed elements on one face of the B30.2 domain.

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