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Adaferin (Adapalene)

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Adaferin is used to treat acne. Adaferin is in a class of medications called retinoid-like compounds. It works by stopping pimples from forming under the surface of the skin. Adaferin has the unique ability to inhibit keratinocyte differentiation and decrease keratin deposition.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Crestor, Catapres, Skelaxin, Neoral, Allegra, Vasomet, Amlobet, Talcilina, Cosaar, Levoquinox, Spinofen,

Also known as: Adapalene


Adaferin is a third-generation topical retinoid primarily used in the treatment of acne. Adaferin is a gel used for the treatment of acne (blackheads, whiteheads and pimples) of the face, chest or back. Adaferin gel is a clear gel that powers deep inside your pores to control the buildup that leads to acne. It helps prevent the formation of new acne lesions, and can also help get rid of lesions already present. Adaferin works under the skin surface to unclog pores and clear up pimples. Adaferin is also known as Adapalene, Adapen, Adaferin. Generic name of Adaferin is Adapalene.


It is very important that you use this medicine only as directed. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause irritation of the skin.

Do not apply this medicine to windburned or sunburned skin or on open wounds.

Do not use this medicine in or around the eyes, lips, or inside of the nose. Spread the medicine away from these areas when applying. If the medicine accidently gets on these areas, wash with water at once.

Apply the medicine to clean, dry areas of the skin affected by acne. Rub in gently and well. Wash your hands afterwards to remove any medicine that may remain on them.

To help clear up your acne completely, it is very important that you keep using this medicine for the full time of treatment , even if your symptoms begin to clear up after a short time. If you stop using this medicine too soon, your acne may return or get worse.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For topical dosage form (gel): For acne: Adults and teenagers—Apply a small amount as a thin film once a day, at least one hour before bedtime. Apply the medicine to dry, clean areas affected by acne. Rub in gently and well. Children—Use and dose must be determined by your doctor.


If you overdose Adaferin and you don't feel good you should visit your doctor or health care provider immediately.


Store at a room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Adaferin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of adapalene in the elderly with use in other age groups. Older adults are not likely to develop acne.

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Acute renal failure in patients with sepsis in a surgical ICU: predictive factors, incidence, comorbidity, and outcome. Th1 cytokines facilitate CD8-T-cell-mediated early resistance to infection with Mycobacterium tuberculosis in old mice. The effect of protein depletion and refeeding with a normal diet on mouse liver soluble homogenate calpain activity was studied. New observations emerging from refined dating techniques, paleoecology and modeling suggest that the megafaunal collapses of the Americas and Australia, as well as most prehistoric island biotic losses, trace to a variety of human impacts, including rapid overharvesting, biological invasions, habitat transformation and disease. Considering the result of ultrastructural and histochemical studies, the pigment was considered most likely neuromelanin. To investigate whether the previously reported association between IL-1alpha mRNA levels and survival in urinary bladder cancer remains in an extended patient material and to search a mechanism behind a possible antitumoral activity of IL-1alpha. The development of sleep-wakefulness cycle and its correlation to other behavior in the human fetus. A patient with acute cardiomyopathy was discovered to have been taking Fenfluramine and Mazindol at the prescribed dose. Utilization of lesser sac endoscopy in patients with gastric carcinoma minimized the number of exploratory laparotomies 6.4 times in comparison with only laparoscopy use and was responsible for diminishing this number to 5 per cent of the total number of examined patients. High liquid recirculation rates and automated pH control were critical for stable filtration performance.

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Report of a Case of Melanosarcoma of the Orbit Treated with Radium. After a short description of the different subtypes of stroke and their age distribution the possible risk factors are discussed. Exploratory tympanotomy is needed to verify the occurrence of leakage. Accurate pulse rate detection is essential for reliable pulse rate variability analysis. Synthesis of methyl O-(3-deoxy-3-fluoro-beta-D-galactopyranosyl)-(1----6)-beta-D- galactopyranoside and methyl O-(3-deoxy-3-fluoro-beta-D-galactopyranosyl)-(1----6)-O-beta-D- galactopyranosyl-(1----6)-beta-D-galactopyranoside. Xanthates As Useful Probes for Testing the Active Sites of Cytochromes P450 4A11 and 2E1. The neutral protease activity is likely to mediate the activation of inactive prorenin. The analyses showed that thinspiration and bonespiration content contained more thin and objectified bodies, compared to fitspiration which featured a greater prevalence of muscles and muscular bodies. Data on redistribution of calcium in the cells, its binding with calmodulin and participation of glucose metabolites in the insulin secretion are discussed. The first transplantable cells appeared mostly in the thymus, and only in two cases in the bone marrow.

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The multiple interactions of the different cells involved in fibrogenesis, the findings that combinations of growth regulators may act additively, synergistically or antagonistically, the fact that certain growth regulators induce the synthesis or receptor expression of others and even of themselves and, findings suggesting an interaction between growth regulators, cell surface receptors, binding proteins (scavengers) and extracellular matrix components indicate a very complex network in fibrogenesis. Necroses of the gluteal region following vascular surgery interventions. With larger populations (2 x 10(5) per ml), some survivors were present after heating at 60 and 80 C for 15 min. This is a further argument in favor of an essential role of base-mispairing during initiation. Using the fee schedule at our institution, the cost-effectiveness was analyzed based on the cost savings from treatment changes and the additional expense of implementing the high-dose studies. A lower band gap as well as a wider absorbance in the UV-, vis- and NIR-regions can increase the light harvesting ability of the Bi2S3/C-dots.

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The suggestion is advanced, in view of the reputed sedimentation behaviour of yeast peroxisomes, that the closed-circular DNA of buoyant density 1.701 g/cm(3) may be located in peroxisomes. Findings generally support the frontal aging hypothesis and may provide important information about healthy cognitive aging. Relationship of the syndrome to central nervous system granulomatous angiitis. Exposure was from less than 10 to up to 100 times lower in expected and/or published results for offshore food and water, respectively. We describe a method to increase arterial oxygenation and to ensure stability of O2 and CO2 during carbogen breathing in patients with malignant disease. We reviewed 5 patients who underwent this procedure between 1995 and 1997 with a single mucosal cancer of the stomach that was unsuitable for en bloc excision by endoscopic snare diathermy. The child was well postoperatively until day 9, when he developed fever. Ovarian diapause in three geographic strains of Culex pipiens (Diptera: Culicidae). In addition, VIP-, GRP- and somatostatin-like immunoreactivities were detected in myelinated nervous bundles. In five additional patients with indeterminate solid lesions and negative aspirations, sonography was successfully used for preoperative wire placement.

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