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Actos

Actos is a once-daily oral medication for people with type 2 diabetes. Part of the anti-diabetic drug class known as thiazolidinediones. It works by increasing the body’s sensitivity to its own insulin, allowing the hormone to work more effectively at improving blood glucose control.

Other names for this medication:
Diamet, Diavista, Diazero, Dibiglim, Euroglip, Gamaryl, Geoglit, Glimestar, Glimitab, Glitafor, Glito, Glitter, Glucut, Glycinova, Glyree, Matce, Mepride, Metme, Metride, Pglit, Pianorm, Pioglar, Pioglu, Piokind, Piomeri, Pioryl, Prichek, Radizone, Triglimiprex, Triglycomet, Trigulin, Vedapride, Walaphage, Zorep

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Also known as: Pioglitazone

Description

You should take Actos according to your doctor’s or healthcare provider’s instructions.

Actos comes as a tablet that you swallow.

When to take

You’ll take Actos once a day. Try to take this medication at about the same time each day.

Don’t take more than one dose in a day.

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Taking Actos with food

You can take Actos tablets with or without food.

Can Actos be crushed, split, or chewed?

No, you shouldn’t break, crush, split, or chew Actos tablets. Broken tablets haven’t been studied, so it’s not known if it’s safe to take a tablet that’s broken.

If you’re having trouble swallowing your Actos tablets, talk with your doctor. They may be able to suggest ways to help you take your medication or recommend other drugs that may be easier for you to take.

Dosage

The Actos dosage your doctor prescribes will depend on several factors. These include:

  • the type and severity of the condition you’re using Actos to treat
  • other medical conditions you may have, such as congestive heart failure (CHF)*
  • other medications that you’re taking to treat your type 2 diabetes
Typically, your doctor will start you on a low dosage. Then they’ll adjust it over time to reach the amount that’s right for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

* <em>Actos</em> has a<em> boxed warning</em> for CHF. This is the most serious warning from the FDA. For more information, see “FDA warning: Congestive heart failure” at the beginning of this article.

Drug forms and strengths

Actos comes as a tablet that you swallow, and you’ll usually take it once a day. Actos is available in three strengths: 15 mg, 30 mg, and 45 mg.

Dosage for type 2 diabetes

Your doctor will likely have you start taking either a 15-mg or 30-mg dose of Actos once a day. If needed, they may increase the dose by 15 mg for extra control of your blood sugar. The maximum dose of Actos is 45 mg a day.

Your starting dose will depend on if you have other health conditions, such as CHF.* And the dose will be increased over time based on how your body responds.

And in some situations where your body may be very stressed, your doctor may need to change your dose or have you stop taking Actos. So tell your doctor right away if you:

  • have a fever
  • have an infection
  • have had an accident
  • have just had or will have surgery
Never change your dosage of Actos without first talking with your doctor. And before you start taking Actos, be sure to tell them about any medical conditions you have or any other medications that you take. Your doctor will determine what the best dosage is for you.

* Actos has a boxed warning for CHF. This is the most serious warning from the Food and Drug Administration (FDA). For more information, see “FDA warning: Congestive heart failure” at the beginning of this article.

What if I miss a dose?

If you miss your dose, wait and take Actos when your next dose is due. Never take two doses in 1 day. If you have questions on when to take your next dose of Actos after you’ve missed a dose, talk with your doctor or pharmacist.

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Will I need to use this drug long term?

Actos is meant to be used as a long-term treatment. If you and your doctor determine that Actos is safe and effective for you, you’ll likely take it long term.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. You may have signs of low blood sugar, such as extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Actos are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.

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The vascularization of the neural isolated pars ventralis of the tuber cinereum--hypophysis of the frog, Rana temporaria. Quantification and deconvolution of the Chl a fluorescence transients into several phenomenological and biophysical parameters (JIP-test) revealed large genotypic differences in the response of PSII to dark chilling. To evaluate the prognosis of HIV-infected patients admitted to ICUs and to identify factors predictive of short- and long-term survival. The use of nonsteroidal anti-inflammatory agents is also discussed in the context of the elderly patient in whom physiologic aspects of aging must be considered. It is apparent that chemotherapy alone is sufficient treatment in this select group of patients.

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Life-spanning behavioural and adrenal dysfunction induced by prenatal hypoxia in the rat is prevented by the calcium antagonist nimodipine. Advanced fibrosis may explain the female and age association with stroke in AF. Phenotypic characterization of the proliferating cells confirmed their vascular origin. Analogous changes in the afferent flow were observed when adequate excitations were provided by stretching and cooling of skin. The results of our experiments explain both how excess Rbl2p can rescue cells overexpressing beta-tubulin and how it can be deleterious in a wild-type background. The Omnibus Budget Reconciliation Act of 1987 radically redefined the relationship between nursing facilities and their residents. Repeated challenge caused airway obstruction and remodeling that persisted for at least 24 h.

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A placebo (saline) vaccination group was used to investigate the variability of clinical outcome scores with a 4weeks interval. Diabetes increases the risk of all clinical manifestations of CHD, has a greater impact in women, and predisposes to cardiac failure and fatal outcome. Both MGST1 and cytosolic GSTs catalyzed the denitration of GTN, but the activity of MGST1 toward GTN was 2- to 3-fold higher. Behavioral estimates of interhemispheric transmission time and the signal detection method: a reappraisal. THE INFLUENCE OF DENITROGENATION ON THE RESPONSE OF ANESTHETIZED DOGS TO INTRAVENOUSLY INJECTED OXYGEN. Organochlorine pesticides in the surface waters of Northern Greece. The inhibitor is able to exert its action as long as it is added during the G1 progression and before the cells enter in S phase. The AHA recently released revised guidelines for CPR and emergency cardiovascular care.

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Megalin-dependent internalization of cadmium-metallothionein and cytotoxicity in cultured renal proximal tubule cells. Convection-enhanced delivery (CED) is a novel technique used to deliver agents to the brain parenchyma for treatment of neoplastic, infectious, and degenerative conditions. Altered opioid concentrations probably play a central role in the pathogenesis of pruritus. We report a case of a patient with this complication who had massive thrombosis within the descending thoracic aorta detected by transesophageal echocardiography. Some international trends in the incidence cordarone dose de charge acfa of neural tube defects. Further, several receptors including the laminin receptor, the fibronectin receptor and a hyaluronic acid receptor, display specific expression patterns during heart development. Proceedings: Pharmacological studies on the superior cervical ganglion reinnervated by the afferent vagus. Cytochrome P450arom was expressed in the trophoblast as well as the hypoblast under the embryonic disc.

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Upon VacA intoxication, VacA was visualized to co-migrate along with fasI and finally induced vacuolation coupled with dramatic redistribution of fasI molecules. This paper assimilates the current evidence concerning the substrates and activities of DUBs that regulate protein trafficking. The results show that hypoxanthine phosphoribosyltransferase deficiency itself, rather than an effect of another X-linked gene, causes a reduced level of contribution to haematopoietic tissues. Males had more cardiovascular procedures than females (3.4 million versus 2.5 million), while females had more operations on the digestive system than males (3.0 million versus 2.2 million). Radio frequency radiation (RFR): the nature of exposure and carcinogenic potential. Great attention has been devoted to the improvement of quality of the training process, entirely analyzed in order to transform OSH training into a real investment to companies and workers. Generation and characterization of chimeric recombinant AAV vectors. Affinity for ATP was found to be almost 7-fold greater in adults when compared to neonates. The action of hyperosmotic stress on the MAP kinase phosphatase MKP-1 mRNA expression was studied in H4IIE rat hepatoma cells.

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Acquired immune deficiency syndrome: an update and interpretation aygestin 5 mg oral tablet norethindrone . A midwifery practice offers an ideal setting to study the relationship of hand techniques by the birth attendant to reduction of genital tract trauma. Guidelines for discontinuing prehospital CPR in the emergency department--a review. When Escherichia coli BUG-6 is grown at 42 C and then returned to 30 C, the division kinetics during the recovery at 30 C are dependent on the length of time the cells were grown at 42 C. In this study was performed to construct genetic map and quantitative trait loci (QTL) analysis. Intrastromal corneal ring implantation (360 degrees ring) for myopia: a 5-year follow-up. Cardiac Autonomic and Blood Pressure Responses to an Acute Bout of Kettlebell Exercise. In addition, it has both beta-1,4-linked L-arabinopyranosyl and beta-1,6-linked D-galactopyranosyl residues. It was shown that the antisera selectively recognized the reduced and oxidized forms of glutathione and that they did not exhibit any significant crossreactivity with glutamate, cysteine, glycine, gamma-glutamyl-cysteine or cysteinyl-glycine. More specifically, it is suggested that persons with posttraumatic impairments in arousal, speed of processing, and possibly attention may benefit most from treatment with an agent that augments cerebral catecholaminergic function, and that persons whose predominant posttraumatic impairment is in the domain of memory may benefit most from treatment with cholinesterase inhibitors.

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