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Actirax (Alprazolam)
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Actirax

Actirax is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Actirax, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Actirax is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Actirax, Alcicalm, Aldep, Alpracon, Alprastan, Alprawin, Alprosym, Alzoft, Anlzium, Anxico, Ateez, Cooltime, Dexolam, Emlol, Fludep, Flunix, Golprax, Indolam, Notence, Pacyl, Prolam, Sertamax, Somnia, Tenfree, Tenschem, Trapose, Zolam, Zoldac, Zopral

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Also known as: Alprazolam

Description

Actirax XR (alprazolam) is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Alprazolam affects chemicals in the brain that may become unbalanced and cause anxiety.

Actirax XR is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

Actirax XR may also be used for other purposes not listed in this medication guide.

Dosage

Take Actirax exactly as prescribed by your doctor. Follow all directions on your prescription label. Never use Actirax in larger amounts, or for longer than prescribed. Tell your doctor if the medicine seems to stop working as well in treating your symptoms.

Actirax may be habit-forming. Never share Actirax with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

Misuse of habit-forming medicine can cause addiction, overdose, or death. Selling or giving away this medicine is against the law.

Do not crush, chew, or break a Actirax extended-release tablet. Swallow the tablet whole. Call your doctor if this medicine seems to stop working as well in treating your panic or anxiety symptoms. Do not stop using Actirax suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

Overdose

If you have been prescribed Actirax for medical reasons, the best way to avoid a Actirax overdose is to adhere to prescribed orders—closely monitor your dose and the time at which you take your medication. Track your Actirax consumption in a notebook or on your phone. If you notice that you are taking a higher dose of the drug, taking the drug more often, or you want to consume more of the drug, talk with your doctor immediately.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details.

Side effects

The most common side effects associated with Actirax are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Disseminated Pneumocystis carinii infection involving the neck and nasopharynx. The results indicated that heavy workload, personal safety, inadequate pay, role overload, and poor working environment are stressors of DQNT. The promise of therapies targeted to the specific molecular pathways altered by such mutations has made genetic testing in nonsmall cell lung cancer (NSCLC) attractive to clinicians. Mammalian GTP cyclohydrolase I is a decameric enzyme in the first and rate-limiting step in the biosynthesis of tetrahydrobiopterin, which is an essential cofactor for enzymes producing neurotransmitters such as catecholamines and for nitric oxide synthases. Ectopic expression of a tobacco vacuolar invertase inhibitor in guard cells confers drought tolerance in Arabidopsis. We subcutaneously administered two dose combinations of MMB (0.45 / 6 / 7.5 and 0.9 / 12 / 15 mg/kg) in mice, followed by administration of atipamezole, for reversal of anesthetic effects, after 1 hr. To evaluate the reliability and validity of a comprehensive geriatric assessment tool set for community elderly. As HCWM and patient safety standards keep on changing regularly, the hospital workers especially doctors need to be focused to comply with the standard practices in hospitals. Small bowel and skin toxicity were scored according to the criteria of the World Health Organization. Postsynaptically, syntaxin-1 colocalized in the nanometer range with the N-methyl-D-aspartate (NMDA) receptor subunit NR2B, but only weakly with the AMPA receptor subunits GluA2/3.

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Data will be presented which document pre- to posttreatment improvement in select voice characteristics (sound pressure level, subglottal air pressure, thyroarytenoid laryngeal muscle activity and voice quality) following application of an intensive voice treatment program (the LSVT) to 3 individuals with aged voice. The latter is also commonly called Fourier transform MS (FT-MS). Cardiovascular hemodynamics and the blood flow of hollow viscus and solid organs were evaluated in rats undergoing laparotomy, followed by diagnostic carbon dioxide (CO2) laparoscopy with an intraabdominal pressure of either 4 or 10 mmHg and rapid desufflation of the abdominal cavity. A new test of an old hypothesis: a quantification of sequence in the Rorschach. Ecological control of the bacterial diarrheas: a scientific strategy.

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Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression. The histopathology of sentinel nodes using serial sectioning and cytokeratin immunohistochemistry was compared with that of the nonsentinel nodes evaluated with routine hematoxylin and eosin stain. Accordingly, it predicts that homosexual men should perform in the direction of heterosexual women, and homosexual women in the direction of heterosexual men, on neurocognitive tests that show normative sex differences. Although ILI affects the number of hospital admissions and deaths, we found no consistent influence of influenza, which requires further assessment. After inhalation of carbachol aerosol, 25 subjects showed a significant (P less than 0.05) increase in total respiratory resistance that was prolonged and independent of hay fever history. The aim of this study is to describe the anaesthetic procedure for transfemoral transcatheter aortic-valve implantation and the results on 100 patients with symptomatic severe aortic stenosis. Thus, CBP, which forms part of the promoter complex with CREB, mediates sensitivity to cocaine by acetylating histones.

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Variables that did not demonstrate any significant differences were body mass index, the presence of chronic obstructive pulmonous disease and diabetes mellitus. Currently identified oral PMDs include leukoplakia, erythroplakia, palatal lesions associated with reverse smoking, oral lichen planus, oral submucous fibrosis, actinic keratosis, and discoid lupus erythematosus. When severe, these injuries represent a tremendous challenge to the orthopaedic trauma surgeon. This modification creates a binding site for MBD (methyl-CpG-binding domain) proteins which target chromatin-modifying activities that are thought to contribute to transcriptional repression and maintain heterochromatic regions of the genome. They viewed health holistically and included faith in their perspectives. Piebaldism is a rare autosomal-dominant disorder of melanocyte development characterized by congenital poliosis and stable patches of leukoderma. In a double-blind study, diclofenac sodium (Voltaren)--administered for 14 days in a dosage of 25 mg t.i.d.--was compared with naproxen (250 mg b.i.d. This study focused on the susceptibility of graft tissue surfaces to bacterial adherence as a potential risk factor for subsequent IE. In the end, genetic research approaches to common forms of human epilepsy will enhance understanding of underlying neurobiological mechanisms, and through this understanding will come new treatment options, new molecular markers to improve current diagnostic criteria, and new genetic tests for predicting drug efficacy in patients with epilepsy.

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After completion of glomerulogenesis and nephrogenesis, HIF-1alpha and -2alpha were no longer detectable. A survey was conducted in asthmatic patients attending the emergency department for acute asthma. Novel composite nanoparticles based on glycidyl methacrylate-derivatized dextrans and gelatin as new bone morphogenetic protein carrier. Neurocognitive defects include loss of functioning memory and subtle changes in attention and processing speed. When animals undergo repetitive, aggregating behavior through time, they can create nutrient hotspots where rates of biogeochemical activity are higher than those found in the surrounding environment. A new intracavitary lesion at echocardiography and MR: a case of mistaken identity. Effects of these active peptides were investigated, combining both in vitro and in vivo rabbit models of mucociliary activity from the maxillary sinus and the trachea. Maternal serum cotinine was not related to delayed motor development milestones or reduced motor function abilities in children up to 7 years of age. This paper summarized the analytical methods such as DNPH/HPLC/UV and PFPH/GC/MS used for the determination of carbonyl compounds emitted from plants or in plant leaves. Nearly all previous empirical research has ignored friendship ties and has largely neglected extended-family ties.

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Retinal miRNAs variations in a large cohort of inherited retinal disease. Intradermal adreno-mediator investigation in normal subjects and in autonomic dysfunction. Branchio-oto-renal syndrome: identification of a novel mutation in the EYA1 gene. Image quality and contrast agent exposure in cardiac computed tomography angiography prior to transcatheter aortic valve implantation procedures using different acquisition protocols. The second step was determination of the location of GSR particles by X-ray imaging of Ba or Sn at a magnification of x 1000-2000 in the SEM, using data of map analysis, and the third step was identification of GSR particles, using WDX spectrometers.

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Conceivably, disparate signaling mechanisms trigger common downstream events necessary to secure a successful pregnancy. Coping may be a particularly challenging notion cross-culturally. Chemotherapy with docetaxel should be considered in the treatment of patients with cardiac angiosarcoma. A combined approach to decontamination of a hospital water supply was assessed. In a sizable proportion of both groups there was no relationship between symptoms and electrodiagnostic findings (45 hands and 48 hands in assembly and non-assembly line workers, respectively). The investigation of the effect of laser spectrum width and multiple lasers on speckle contrast is discussed. This study aimed to determine the relationship between emotional intelligence and its related components and the occurrence of accidents/crashes in motorcycle drivers. Based upon an analysis of the self-assembly behavior of dequalinium, a cationic single-chain bolaamphiphile which is known to selectively accumulate in mitochondria, we have developed a whole new strategy for mitochondria-specific DNA delivery. Leptin receptors are widely distributed, both centrally and peripherally, and there are several neuroendocrine targets. The isolated nanofibers had an average diameter of below 10 nanometres and a very high aspect ratio in the range 120-150.

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Impact of Early Screening for Gestational Diabetes on Perinatal Outcomes in High-Risk Women. Nonimmune hydrops fetalis due to maternal parvovirus infection has also been treated successfully with the intravascular transfusion of red cells, whereas fetomaternal hemorrhage has not proved amenable to such therapy. The apparent molecular weight of the preparation was 28,000 based on sodium dodecyl sulfate polyacrylamide-gel electrophoresis and 28,800 based on sucrose gradient centrifugation. Combined effect of individual and neighborhood socioeconomic status on mortality in patients with newly diagnosed dyslipidemia: A nationwide Korean cohort study from 2002 to 2013. Intraperitoneal injection of IL-2 significantly enhanced the scopolamine-induced hyperactivity, whereas the cytokine alone was ineffective in modifying locomotor activity. The particular environment that we address is the vapor-liquid interface, since only a few, limited studies have explored the influence of an interface on equilibrium reaction behavior.

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One hospital has developed an institutional policy to guide decision making between physicians and pregnant patients. To evaluate the health status of older persons in Botswana, to report on the prevalence of common health conditions--typically chronic diseases, to assess the socio-demographic correlates of morbidity in this population, and to assess the associations between physical functioning and self-reported health and the common health problems presented. Human infections are usually precipitated by local or systemic predisposing factors, and disseminated infection is associated with impaired immune responses. The association between procedure volume and post-procedure outcomes such as mortality or perioperative complications has been studied since the 1970s for a wide variety of procedures. Modeling of specular X-ray reflectometry data indicated that thinner and more electron dense layers on salt subphases best fit the observed profiles. Water cost and availability: key determinants of family hygiene in a Peruvian shantytown. Contributions of Trf4p- and Trf5p-dependent polyadenylation to the processing and degradative functions of the yeast nuclear exosome. A synthesis of evidence found major gaps in essential medicine access in Pakistan driven by weaknesses in the health care system as well as weak pharmaceutical regulation. To assess white matter (WM) and gray matter (GM) magnetization transfer ratio histogram peak heights (MTR-HPHs) in different subsets of patients with neuropsychiatric systemic lupus erythematosus (NPSLE) who have unremarkable findings on 3T magnetic resonance imaging of the brain and to evaluate whether these values could be used to highlight different clinically suspected underlying pathogenic processes or identify the clinical NPSLE status or whether they could be associated with a specific NPSLE syndrome. between 1991 and 1999 19 patients underwent angioplasty with selective stenting for recurrent stenosis after previous aortoiliac endarterectomy.

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Detection platforms fabricated using this approach exhibit exceptionally low concentration and mass detection limits down to 15 nM and 9.8 amol, respectively, for bovine serum albumin (BSA) as a model protein. The present study was designed to determine whether ketamine could maintain hepatic circulation and oxygen metabolism even in the presence of serious hepatic hypoxia. Further, the development prospect of pollution control technique in the recycle of HME and the challenges must face up to are also probed. Blacks with chronic illness have poorer outcomes than whites in the United States. Before percutaneous transluminal recanalization of the chronic occlusion of the superficial femoral artery the authors induced by means of a balloon catheter short-term occlusion of the deep femoral artery in its central portion, closely after its insertion (complete block of the heterocollateral circulation) and in the periphery of this artery (partial block of the collateral circulation). We applied a speckle-tracking algorithm to US B-mode images for strain calculations. We used data from seven waves (2002-2009) of the Survey of Family, Income and Employment, restricted to a balanced panel of adults in families. The first modifications were those in the side chain of the molecule, which are expected to affect, either or both, the steps of binding to transfer protein or the interaction with catabolic enzymes.

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Our results suggest that the features, relative blood concentration, and oxygen saturation can differentiate breast tumors with a relatively high precision. Our findings suggest that Pneumocystis has developed unique mechanisms of adaptation to life exclusively in mammalian hosts, including dependence on the lungs for gas and nutrients and highly efficient strategies to escape both host innate and acquired immune defenses. Leadership styles in ethical dilemmas when head nurses make decisions. The results of electrophysiologic studies in 17 patients with the cardioinhibitory type suggest that intrinsic sinus nodal dysfunction is not the major cause for asystole after carotid sinus stimulation. The diagnostic value of tests for antimyeloperoxidase antibodies (anti-MPO) for systemic vasculitis is less established than that for cytoplasmic antineutrophil cytoplasmic antibody (cANCA)/antiproteinase 3 antibodies (anti-PR3). The use of suture anchors and tacks around the shoulder requires a thorough knowledge of the proper use of the devices and how to insert them. The primary indication for PEA should be pain relief for open abdominal or thoracic surgery because there is level 1 evidence that it provides better analgesia than parenteral opioids. Although in part it may be genetically mediated, a number of environmental factors (allergens, viruses and contaminants) are also involved in increasing bronchial responsiveness through airway inflammation. We measured lost productivity and use of health/social care, criminal justice system and informal care at baseline and one year to estimate and compare mean total costs from health/social care and societal perspectives. Skin Sympathetic Nerve Activity is Modulated during Slow Sinusoidal Linear Displacements in Supine Humans.

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The alpha1(S270I) mutation itself rendered the GABA(A)R more sensitive to GABA and reduced the Hill coefficient. Analysis of cardiomyocytes isolated from CFKO mice showed increased length but not width. By incrementally increasing the heat load from 41-55 degrees C, we observed a gradually increase in apoptosis with a significant change from apoptotic to necrotic death at temperature beyond 45 degrees C. The treatment of osteomyelitis in the distal parts of the extremities often requires additional skin flaps (25 operations), rarely free skin grafts. We tried to present the main recommendations of the American Thoracic Society and the European Respiratory Society of lung adenocarcinoma. Frail phenotype might herald bone health worsening among end-stage renal disease patients.

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